MicroRNA regulation of HNF4A
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چکیده
منابع مشابه
ROCK inhibition enhances microRNA function by promoting deadenylation of targeted mRNAs via increasing PAIP2 expression
The reduced expression levels and functional impairment of global miRNAs are related to various human diseases, including cancers. However, relatively little is known about how global miRNA function may be upregulated. Here, we report that global miRNA function can be enhanced by Rho-associated, coiled-coil-containing protein kinase (ROCK) inhibitors. The regulation of miRNA function by ROCK in...
متن کاملIn silico and in vitro identification of microRNAs that regulate hepatic nuclear factor 4α expression.
Hepatic nuclear factor 4α (HNF4A) is a nuclear transcription factor that regulates the expression of many genes involved in drug disposition. To identify additional molecular mechanisms that regulate HNF4A, we identified microRNAs (miRNAs) that target HNF4A expression. In silico analyses suggested that HNF4A is targeted by many miRNAs. We conducted in vitro studies to validate several of these ...
متن کاملGlucocorticoid receptor regulates organic cation transporter 1 (OCT1, SLC22A1) expression via HNF4a upregulation in primary human hepatocytes
Background: Organic cation transporter 1 (OCT1, SLC22A1) is a membrane transporter that is important for therapeutic effect of the antidiabetic drug metformin. Its liver-specific expression in hepatocytes is strongly controlled by hepatocyte nuclear factor-4a (HNF4a). HNF4a expression and transcriptional activity have been demonstrated to be augmented by glucocorticoid receptor (GR) in human he...
متن کاملA Systematic Analysis of the 3′UTR of HNF4A mRNA Reveals an Interplay of Regulatory Elements Including miRNA Target Sites
Dysfunction of hepatocyte nuclear factor 4α (HNF4α) has been linked to maturity onset diabetes of the young (MODY1), diabetes type II and possibly to renal cell carcinoma (RCC). Whereas diabetes causing mutations are well known, there are no HNF4A mutations found in RCC. Since so far analyses have been constricted to the promoter and open reading frame of HNF4A, we performed a systematic analys...
متن کاملDGAT1 participates in the effect of HNF4A on hepatic secretion of triglyceride-rich lipoproteins.
OBJECTIVE Hepatocyte nuclear factor-4alpha (HNF4A) is a transcription factor that influences plasma triglyceride metabolism via an as of yet unknown mechanism. In this study, we searched for the critical protein that mediates this effect using different human model systems. METHODS AND RESULTS Up- and downregulation of HNF4A in human hepatoma Huh7 and HepG2 cells was associated with marked ch...
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